The trace element zinc plays a vital role in scores of biochemical pathways. Zinc is needed for normal growth and development, healthy reproductive systems, strong immunity function, DNA synthesis, protein synthesis, carbohydrate metabolism, enzymatic reactions, gene expression, and muscle growth and recovery. Zinc, along with magnesium, is found in most testosterone booster supplements.
Resveratrol is considered one of the best free radical scavengers. It helps neutralize the free radicals in the body, and in addition, it activates other antioxidants such as catalase and glutathione. There is a lot of research underway to find how resveratrol works and how it can benefit us. Some of the most well-known benefits of resveratrol include reducing cholesterol, acting as an anti-aging supplement, supporting bodybuilding, helping with weight loss, enhancing brain health, improving cardiovascular health, fighting cancer, etc.
Oxiracetam is a nootropic derived from piracetam in the 70s. The supplement’s chemical structure and MOA are a lot like piracetam, but only more potent. Many compare its stimulant properties to that of phenylpiracetam, but only more powerful.
Oxiracetam offers a wide range of benefits from wakefulness, enhanced memory, to neuroprotection. The nootropic is considered safe, well-tolerated, and effective for short- and long-term therapy.
Melatonin is produced in the pineal gland in the brain. The hormone is widely known for its role in promoting sleep by regulating the circadian rhythm. Melatonin delivers several other benefits by alleviating stress and anxiety. In addition, the hormone is a powerful antioxidant and neuroprotectant; neutralizing free radicals and flushing out toxins that cause neurodegeneration.
An essential element and the fourth most abundant mineral in the body – magnesium – is a cofactor in hundreds of chemical reactions. It influences myriad functions including energy production, protein synthesis, regulating blood glucose, controlling blood pressure, and impacting mood, and enhancing cognitive faculties. It’s also known to improve sleep and assist muscle growth.
A wide variety of plants, especially fruits, contain beneficial substances called bioflavonoid. These compounds are known for their powerful anti-oxidant and anti-inflammatory properties. One such potent bioflavonoid, mainly found in tangerines, lemon, grapefruit, and oranges, is Hesperidin.
Herperidin provides many benefits including cognitive enhancement, better sleep, better heart health, hot flash relief, and cancer treatment.
Often referred to as the master antioxidant, Glutathione is made up of glycine, cysteine, and glutamic acid. There are two types of Glutathione: GSH and GSSG. Glutathione supplements are usually made of GSH (reduced glutathione), which is the active form that offers maximum benefit. In addition to its effect as a potent antioxidant, Glutathione also reactivates and boosts the performance of other antioxidants.
The aromatic plant fenugreek has some amazing health properties. The tiny seeds of the plant are nutrient-dense, containing fiber, fat, protein, vitamin B6, magnesium, copper, manganese, phosphorus, and iron. The herb is known to boost sex drive, improve exercise performance, reduce inflammation, regulate cholesterol, support digestive health, and do a lot more. In addition, fenugreek added to spice blends can enhance the flavor of curries and other dishes.
A form of aspartic acid, the supplement D-Aspartic Acid is typically prescribed to increase testosterone levels. This is a non-essential amino acid that takes part in numerous vital functions including maintaining reproductive health, cardiovascular health, and assisting in increasing muscle mass and strength.
Sudden testosterone boost is temporary; usually, the hormone reverts to its normal levels in a week or so. Hence, regular use of D-Aspartic Acid is recommended to maintain higher testosterone levels.
Bacopa Leaf Powder – the nootropic derived from hyssop – is primarily used as a mood booster and cognitive enhancer. The herbal nootropic is known for its powerful anxiolytic and antioxidant properties.
Most antidepressants treat the physical and cognitive damages caused by stress. Bacopa outperforms other drugs by preventing and resisting such stress-induced damage from affecting the body in the first place.
The benefits of ashwagandha are quite extensive, even though its exact mechanism of action is still subject to great speculation. Researchers believe the herb has powerful antioxidant, neuroprotective, adaptogenic, and anti-microbial properties. It is also used as an aphrodisiac and a sleep promoter. All these properties and more are because of Withanolide-D and Withaferin-A – the main active ingredients in Ashwagandha.
Apigenin – the compound that has made chamomile tea so popular is one of the members of the flavonoid group. Like other bioflavonoids, Apigenin is also a potent antioxidant, anti-inflammatory, anxiolytic substance. It’s often added to sleep aid supplements to reduce stress, anxiety, and calm the users so that they can fall asleep faster.
Pyritinol is a nootropic supplement that has a positive effect on mood, focus, memory, learning, and reaction time. Researchers believe Pyritinol improves various cognitive abilities by increasing the levels of dopamine and acetylcholine. It’s also known to optimize glucose utilization in the brain. Pyritinol is used as a nootropic supplement to boost cognition and as a clinical medicine to treat various conditions.
Centrophenoxine is one of the earliest Nootropics to be developed in the late 1950’s in France. Also referred to as meclofenoxate or Lucidril, this nootropic is the combination of Dimethylethanolamine (DMAE) and Parachlorphenoxyacetic Acid (pCPA). It was originally developed to treat age-related cognitive decline, senile memory loss, and cerebral insufficiency. As a cognitive enhancer, Centrophenoxine is used as a standalone supplement and as a choline source along with other nootropics in a stack.
Adrafinil is a good alternative to Modafinil. In fact, once inside the liver, Adrafinil converts to Modafinil. Like modafinil, this nootropic supplement is an effective stimulant that’s mainly used to increase alertness, focus, and concentration. Adrafinil is a psychostimulant that is not regulated and easier to buy in the United States.
Inositol often referred to as Myo-inositol, is a pseudovitamin produced in our body. As a nootropic, Inositol supplement is used to improve energy level, mood, and sleep patterns. Its most widely used to treat anxiety, depression, panic attacks, and Obsessive Compulsive Disorder (OCD). Inositol helps fight memory loss, Alzheimer’s, and other similar disorders by aiding regeneration of neurons in the brain.
The Chinese were using Club Moss – the parent plant of Huperzine A – long before the west took notice of its cognitive benefits. The natural nootropic supplement Huperzine A is the purified extract of the Huperzia serrata plant that’s commonly found in China, Southeast Asia, and India. The supplement is frequently used to prevent cognitive decline, improve memory function, and help promote other cognitive abilities.
Phenibut is an indispensable part of any nootropic stack intended to decrease stress, reduce anxiety, and enhance mood. It is designed to replicate and promote the neurotransmitter GABA in the brain. Interestingly, the nootropic supplement was derived by adding a phenyl group to the chemical structure of the neurotransmitter.
There is a new nootropic in town and it’s gaining plenty of attention from both the public and media. Derived from Piracetam, the new arrival, Phenylpiracetam, is said to be 30 – 60 times stronger than its parent. Research suggests that Phenylpiracetam possesses psychostimulatory, neuroprotective, and physical performance enhancing properties. In addition, Phenylpiracetam is quickly making a name for itself as a safer alternative to Adderall.
Spanish Sage is a herb with small leaves and lavender flowers. Its leaves are used to make oil. As a nootropic, Spanish Sage is used to calm the mind and improve memory functions. Spanish Sage’s benefits are backed by a study done by the Northumbria University. The biggest benefit of using Spanish Sage is that it helps fight age-related cognitive decline. The herb is also an anti-spasmodic, used in the treatment of muscle cramps and spasms.
L-phenylalanine is a form of Phenylalanine – an amino acid that aids production of protein. Since our body needs it, but can’t produce it, we need to take it from food sources or as a supplement. To boost the potency of the supplement, it’s usually taken with vitamins (C, B3, and B6), iron, and copper. Phenylalanine or Phenylalanine offer many mental health benefits.
Coleus Forskohlii is used in traditional Ayurvedic medicine to help libido, weight loss, lung and heart functions. Other health benefits, according to the Natural Medicines Database include insomnia, urinary tract infections, irritable bowel syndrome, skin problems, and obesity. Its antioxidant properties fight age-related cognitive decline. Although Coleus Forskohlii benefits are many, the supplement is widely used for supporting weight loss, increasing testosterone, and improving cognitive functions such as memory and mood.
Artichoke and Forskolin extract are fast becoming popular as nootropic supplements. Using these two extracts in a nootropic stack can boost memory formation and retention. The Artichoke and Forskolin combo is ideal for anyone wanting to learn, retain, and recall at will. Artichoke is a repository of healthy vitamins and nutrients. The supplement can be extracted from the plant’s root, stem, or leaves.
Acetyl-L-Carnitine is an amino acid that’s produced in the body to some degree. This amino acid is used by the cells to generate energy. It’s quite popular with bodybuilders and athletes. Health benefits of Acetyl-L-Carnitine include improving mental energy, enhancing memory, increasing focus, supporting weight loss, encouraging athletic performance, treating age-related memory deficits, etc.
Vitamins B12 or Cobalamin has a significant impact on neurological health. Its presence is essential for normal functioning of the nervous system and brain and its deficiency leads to different cognitive disorders. Studies have established Vitamin B12’s role in various cognitive functions such as reasoning, concentration, learning, and memory. Vitamin B12 is also involved in neuron development.
Vitamin B6 or Pyridoxine is the most important vitamin for cognitive health. It’s key to the synthesis of neurotransmitters and energy metabolism in the cells. Vitamin B6 deficiency can lead to cognitive decline, brain shrinkage, fatigue, lack of focus, and cognitive disorders. Supplementing Vitamin B6 can reduce age-related brain cell damage, enhance communication between neurons, and boost physical and mental energy.
Vinpocetine is a natural chemical occurring in Vinca Minor – a type of periwinkle plant. It offers nootropic and other health benefits. As a nootropic, Vinpocetine is widely used for focus, learning, memory, fatigue, and alertness. It’s also used as a treatment option for Alzheimer’s disease and other age-related cognitive disorders.
Rhodiola Rosea or Golden Root is a natural cognitive enhancer that’s typically found in high altitude regions. It has been in use in places with cold climates to improve mood and fight depression. It’s also consumed as food in many parts of the world. Rhodiola Rosea’s cognitive function enhancing benefits includes alleviating stress, improving concentration, reducing fatigue, and boosting energy.
Pterostilbene is a natural nootropic that’s present in certain plants and food items such as grapes, cranberries, and blueberries. In many respects, Pterostilbene is closely related to Resveratrol, which is found in red wine. Several studies have shown strong links between Pterostilbene and longevity. The supplement also contributes to the enhancement of many cognitive functions.
Phosphatidylserine is actually a form of fat that’s present in the body. The brain, especially the cell membranes of neurons, contains half of the total Phosphatidylserine in our body. Phosphatidylserine, taken as a supplement, can improve memory, increase learning capacity, enhance mental energy, and give a boost to the general cognitive health.
Creatine is a nitrogenous organic acid used widely in muscle building. Of late, it’s gaining attention for being a nootropic. Although our body is capable of adequately producing Creatine, to enhance cognitive capabilities supplementation is necessary. As a nootropic, Creatine improves metabolic function in the brain, ensures neuron health, and increases mental energy.
Sulbutiamine nootropic supplement is an enhanced version of thiamine (most popularly known as Vitamin B1). As a supplement, Sulbutiamine is shown to improve focus, concentration, decision making, learning, memory, and many other cognitive functions. Although Sulbutiamine can be taken alone, it’s best used in a stack to boost its benefits.
Noopept is a popular peptide that’s believed to be 1000 times more powerful than piracetam. It’s one of the strongest nootropic supplements currently available for use. Noopept offers many cognitive benefits including improvement in focus, concentration, learning ability, and memory. Noopept is the go-to nootropic supplement for many students who want to improve their memory and learning ability.
N-Acetyl L-Tyrosine or NALT is an amino acid that’s steadily growing in popularity as a nootropic supplement. This substance plays a crucial role in a number of bodily functions such as cell growth, cell recovery, building muscles, and cognitive capabilities. Regular use of the supplement NALT can help both the brain and body.
Modafinil is a smart drug used in the United States under the brand name of Provigil. It was approved by the USFDA in 1998 and is used for obstructive sleep apnea, shift work issues, attention deficit, and narcolepsy. Other non-approved uses of Modafinil include treating multiple sclerosis, relieving depression, enhancing memory, improving attention span, increasing concentration, and enhancing productivity.
L-Theanine is an amino acid that’s found in plants like green tea and certain types of mushrooms. This natural nootropic has been in use in Chinese medicine for thousands of years for treating various ailments. L-Theanine was first derived in 1949 from green tea and since then various studies have backed its cognitive enhancement abilities. L-Theanine is usually taken along with Caffeine to quell nervousness and anxiety caused by the stimulant.
Caffeine is a popular stimulant that’s commonly added to nootropic stacks. It’s widely used to increase alertness, improve concentration, and enhance energy. Caffeine is a highly effective compound used in energy drinks, diet and weight loss products. In certain situations, Caffeine along with analgesics is used to treat headaches. Caffeine is normally taken in powder or pill form.
Alpha-GPC is one of the most popular choline supplements among nootropic users. It produces choline, which is a precursor to the neurotransmitter acetylcholine. Using Alpha-GPC as a choline supplement offers a broad range of cognitive benefits including mental clarity, faster learning, quick thinking, and better memory. Alpha-GPC benefits both the brain and the body.
Agmatine is a derivative of the L-Arginine amino acid, but due to its unique development and storage process, it has properties that are quite unlike its predecessor. Agmatine as a supplement has been effective in preventing stroke, tackling drug addiction, treating neuropathic pain, and improving the overall cognitive health. Some experts consider the nootropic supplement as a novel neuromodulator.
Used by millions around the world, Piracetam supplementation offers several benefits to its users. Empirical evidence clearly shows that Piracetam improves the ability to learn, remember, and recall. It makes the learning process easier by enhancing focus, concentration, and motivation. Like other racetams, Piracetam has profound effects on the brain and nervous system.
Coluracetam is one of the newest and lesser known members of the racetam family. According to scientists, the supplement showed great promise in treating Anxiety and Major Depressive Disorders. Coluracetam is believed to be 10 to 20 times more powerful than piracetam. It’s also used to improve vision, enhance focus, increase memory, and improve overall brain function.
Aniracetam is part of the racetam family of Nootropics. It was developed by a Belgium company in the 70s. It’s widely used to help improve a broad range of cognitive functions. Although the supplement is chiefly used to improve focus and memory, the anxiolytic properties of Aniracetam make it an effective mood enhancer.
Galantamine is a well-known Cholinesterase Inhibitor. It inhibits certain enzymes that break down the neurotransmitter acetylcholine. Through its actions, Galantamine increases the levels of acetylcholine, which is responsible for various cognitive functions such as memory, focus, mood, and motivation. In the United States, Galantamine is also used in the treatment of Alzheimer’s disease.
The health benefits of Omega 3 Fatty acids in fish oil are well known. However, not many know the cognitive benefits that fish oil has to offer. Fish oil is one of the best brain foods anyone can find. Pick up a reputed science magazine you’ll find at least one study dedicated to the brain boosting benefits of fish oil.
Lion’s Mane Mushroom, scientifically referred to as Hericium Erinaceus has been used in the Chinese traditional medicine for thousands of years. Of late, it has become very popular among modern Nootropics users. Lion’s Mane Mushroom is regarded as one of the best natural nootropic supplements. Studies have shown that the mushroom is linked to the production of Nerve Growth Factor, has neuroprotective qualities, and it enhances many cognitive functions.
Bacopa Monnieri, also known as Brahmi, is one of the oldest and most widely used cognitive enhancement supplements. In traditional Ayurvedic medicine, Bocaopa Monnieri is used for sharper focus, improved memory formation, memory retention, and better thinking. Brahmi has been used for thousands of years to treat leprosy, inflammation, ulcers, asthma, epilepsy, and even tumors.
Uridine is a natural compound and a precursor to RNA. An adequate level of uridine is necessary for normal functioning of a broad range of cognitive processes. Additionally, uridine has a profound impact on the overall health and wellness of an individual. Studies have found that taking uridine as a nootropic supplement to improve RNA can enhance memory formation and the ability to recall at will.
Citicoline is a highly effective and safe nootropic supplement that metabolizes into uridine and choline. Citicoline, also known as CDP-Choline, improve cognitive functions and boosts the general brain health. Citicoline, on its own, enhances focus, memory, and mental energy. Additionally, when added to a nootropic stack, Citicoline can increase the potency of other supplements.
Pramiracetam is a strong nootropic supplement that can be taken alone or stacked with other supplements to augment its benefits. Hailed as a powerful brain performance optimizer, Pramiracetam is most often used to enhance focus, increase concentration, and improve memory. This outstanding nootropic supplement is fast becoming the favorite of students and professionals.