What is the best Nootropic Supplement?

Seeing you here, we take as a fact you’re, at least partly, convinced that Nootropics can enhance human brain function. It’s true, taking nootropic supplements is a good way to give your brain an extra boost. In this article, by explaining to you how Nootropics work, we intend to make you a firm believer of smart drugs. Nootropics can improve brain function, recall, memory, cognition, and enhance alertness by influencing one or multiple brain elements such as neuroplasticity, hormones, brain waves, neurotransmitters, receptors, cellular energy, and cerebral blood flow.

Best Nootropic Stacks

Nootropic Supplements

Nootropic Sulbutiamine



Sulbutiamine nootropic supplement is an enhanced version of thiamine (most popularly known as Vitamin B1). As a supplement, Sulbutiamine is shown to improve focus, concentration, decision making, learning, memory, and many other cognitive functions. Although Sulbutiamine can be taken alone, it’s best used in a stack to boost its benefits.

Nootropic Phosphatidylserine



Phosphatidylserine is actually a form of fat that’s present in the body. The brain, especially the cell membranes of neurons, contains half of the total Phosphatidylserine in our body. Phosphatidylserine, taken as a supplement, can improve memory, increase learning capacity, enhance mental energy, and give a boost to the general cognitive health.

Nootropic Improve Your Cognition And Productivity With This Nootropic Stack

Improve Your Cognition And Productivity With This Nootropic Stack


When we don’t get the benefit we expect from Nootropics we tend to lose hope and change our course. That’s understandable. But, we need to realize that individual nootropic supplements won’t change our lives. To multiply the benefits of individual Nootropics we need to stack two or more supplements.

Stacking Nootropics is an art in itself. The supplements in a well-combined stack work together to produce a synergistic effect; that is, the combined effect is greater than the individual benefits. The stack we’ve chosen for you today has the potential to increase productivity and enhance several cognitive

Nootropic The Photographic Memory Stack

The Photographic Memory Stack


The ability to recall past actions and events at will depends on the health and vitality of a person’s gray matter. There are several things we can do to train the brain but to keep it healthy and enhance its memory potential we need to feed it with essential nutrients. The Photographic Memory Stack is an ideal combination of Nootropics that can give the brain a surge and enhance our memory potential.

Nootropic Coluracetam



Coluracetam is one of the newest and lesser known members of the racetam family. According to scientists, the supplement showed great promise in treating Anxiety and Major Depressive Disorders. Coluracetam is believed to be 10 to 20 times more powerful than piracetam. It’s also used to improve vision, enhance focus, increase memory, and improve overall brain function.


What Nootropics Really Are?

The huge structures, complex machinery, life-saving medicines, and technological innovations are all proof of the fact that as humans we’re constantly looking for ways to improve ourselves and enhance our brain power.

The Chinese were familiar with the brain enhancing effects of Gotu Kola, Ginkgo Biloba, and Ginseng many thousands of years ago. They were also the first to realize the amazing stimulating properties of tea. It was only recently, a few decades ago, that scientists have come to realize the powerful stimulant properties of tea and coffee.

Let’s move away from mild stimulants and enter the world of powerful brain enhances. While on the one side neuroscientists are exploring the brain and nervous system, an equally dedicated group of experts are using science to come up with substances that can enhance our cognitive faculties.

Special chemical substances that are used to improve our cognitive capabilities are nowadays widely referred to as Nootropics. Nootropics, also called as cognitive enhancers or smart drugs, alter or regulate the chemicals in our brain to achieve the goal we desire.

We take smart drugs to improve mental performance, learn new skills, focus better, remember for a long time, recall at will, memorize more information, and to help us use more of our brain capacity.

The Different Types of Nootropics

A single drug won’t make us smart all of a sudden. There are several brain enhancers and they have all been classified into categories based on the function performed, chemical structure, or their mechanism of action.

Generally, most experts place Nootropics under seven different categories. Normally, we can choose any one group or combine supplements to produce a nootropic stack; the decision depends on what we want to achieve.

A brief introduction to the seven categories of Nootropics is given below.


Racetams hold the distinction of being the first brain enhancers to be developed. Till date, they also happen to be the most popular and widely used Nootropics. The Racetam group has around 20 members; the most well-known ones are Piracetam (the first Racetam to be invented), Pramiracetam, Oxiracetam, Aniracetam, Phenylpiracetam, and Nefiracetam.

All the 20 or so racetams have one thing in common – they activate the brain receptors that are in charge of releasing acetylcholine and they all have a common chemical structure (they share pyrrolidone nucleus).

Acetylcholine is a familiar name to many. It’s one of the most important neurotransmitters in our brain. Improving the level of acetylcholine in the brain can have a very positive impact on cognitive capabilities such as awareness, focus, memory, learning, and motivation.

Racetams are known to perform the dual function. It promotes the growth of brain cells and simultaneously delays the deterioration and death of brain cells. Racetams sometimes exhibit Ampakine-like properties by activating glutamate receptors.


Ampakine is a relatively new category in the world of Nootropics. They are powerful NDMA and AMPA glutamate receptor, agonists. They improve certain cognitive faculties by increasing glutamate levels in the brain.

The Glutamatergic System and neurotransmitter glutamate are said to have a significant impact on synaptic plasticity. This neurotransmitter is directly linked to memory and learning. Researchers say that Glutamate nootropic supplements, when taken in the right doses, can have a beneficial impact on alertness and attention span.

As we discussed above, Racetams sometimes act like Ampakines, but their influence on AMPA receptors is weak. Unifiram and Sunifiram are true Ampakines. When it comes to stimulating AMPA glutamate receptors, Unifiram and Sunifiram are way more powerful than any Racetam Nootropics.

Researchers are still studying the long-term impact of Sunifiram and Unifiram. Hence, certain experts suggest the use of Piracetam (a Racetam with Ampakines-like properties) to activate glutamate receptors.


Those wanting to increase acetylcholine levels in the brain often turn to Choline and Acetylcholine Intermediates. More often than not, the Choline group is stacked with Racetams to ensure better performance.

Choline nootropic supplements ensure additional acetylcholine in the brain, whereas the Racetams activate acetylcholine receptors. Both these actions result in a higher presence of the neurotransmitter, which will invariably result in improving cognitive capabilities.

There are many nootropic supplements that fall under the Choline category, but not all supplements are of equal strength. Some are more effective than others.

Supplements such as Centrophenoxine, Citicholine, and Alpha GPC are powerful acetylcholine intermediates that can be taken alone. These nootropic supplements are safe and don’t cause any side effects. Bear in mind that cheaper alternatives such as Choline Bitartrate are less effective and can cause side effects.

Vitamin-B Derived Nootropics

Synthetically certain types of smart drugs have been derived from vitamins, in particular, Vitamin B. The most well-known supplement that falls under this category is Sulbutiamine.

Derived from Vitamin B1 or Thiamine, Sulbutiamine is used to improve alertness, increase energy levels, and treat fatigue. Research shows the supplement helps users retain what they’ve learned, by increasing the movement of glutamate, dopamine, and choline.

Sulbutiamine has been extensively tried on lab mice and the results have been very positive. A steady dose of this nootropic supplement has enhanced the cognitive function of patients suffering from schizophrenia and Alzheimer’s disease.


The market is flooded with peptide supplements, but the one that’s most sought is Noopept. Noopept is by far the most powerful peptide supplement currently available. It’s mainly used to increase energy, motivation, alertness, learning, and memory.

Developed in Russia, Noopept is sometimes grouped under Racetam, even though technically it’s not a Racetam. Interestingly, it’s a derivative of Racetam. A scientific journal claimed Noopept to be 1000 times more powerful than Piracetam.

Noopept increases the level of acetylcholine by stimulating acetylcholine receptors and induces the release of glutamate by activating NDMA and AMPA receptors. Moreover, Noopept can easily overcome the blood-brain barrier and it’s known for its high bioavailability. Noopept Nootropics perform the function of both Ampakines and Racetams.

Wait, There’s more. Noopept Nootropics help in the growth and maintenance of nerve cells by inducing the release of a protein called Nerve Growth Factor.

Natural Nootropics

Substances derived from plants that exhibit nootropic properties are called Natural Nootropics. They enhance cognitive capabilities and improve brain health without causing any side effects. Substances such as Huperzine-A, Ginkgo Biloba, Vinpocetine, and Bacopa Monnieri are included under this category.

Natural Nootropics aren’t as potent as synthetically made smart drugs. So to augment its power and improve the results two or more natural Nootropics can be stacked together.

Smart Drugs

Although the word nootropics is used interchangeably with smart drugs, it must be noted that all smart drugs are not Nootropics. Certain amphetamine-related substances such as Adderall are actually stimulants. They are not to be associated with nootropics.

There are certain eugeroic drugs that act both as stimulants and Nootropics. For example, Modafinil can stimulate neurotransmitter hypocretin and help increase motivation, energy, and alertness. The stimulant is also prescribed to treat fatigue and sleepiness.

Smart drugs aren’t worth the risk. Hence, we would suggest you avoid stimulants and use only safe nootropic supplements.